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Medication management in children and adolescents with obesity is challenging because both developmental and pathophysiological changes may impact drug disposition and response. Evidence to date indicates an effect of obesity on drug disposition for certain drugs used in this population. This work identified published studies evaluating drug dosing, pharmacokinetics (PK), and effect in pediatric patients...
Objective
Weight regain after weight loss is common, and there is evidence to suggest negative effects on health because of weight cycling. This study sought to investigate the impact of weight regain in formerly obese mice on adipose tissue architecture and stromal cell function.
Methods
A diet‐switch model was employed for obesity induction, weight loss, and weight regain in mice. Flow cytometry...
Objective
Weight regain (WR) after Roux‐en‐Y gastric bypass surgery (RYGB) starts to occur 2 years after surgery, ultimately affecting at least 25% of patients. A limited number of studies have evaluated the impact of antiobesity medications (AOMs) on this phenomenon.
Methods
This study reviewed the electronic medical records of 1,196 patients who underwent RYGB between 2004 and 2015. WR was evaluated...
Objective
This study aimed to perform a preliminary investigation of the impact of combined hormonal contraceptive (CHC) use on weight loss during an 18‐month behavioral weight‐loss trial.
Methods
Adults (n = 170; 18‐55 years; BMI 27‐42 kg/m2) received a weight‐loss intervention that included a reduced‐calorie diet, a progressive exercise prescription, and group‐based behavioral support. Premenopausal...
The global outbreak of the 2019 novel coronavirus disease has had a tremendous psychological impact on individuals around the world. Individuals with obesity are susceptible to distress and psychological sequalae secondary to this pandemic, which can have detrimental effects on obesity management. In particular, individuals undergoing bariatric surgery could experience increased emotional distress,...
Objective
In traditional behavioral weight loss (BWL) programs, young adults fare worse than older adults with respect to engagement, retention, and weight loss, but money and use of technology have been cited as program factors that might improve outcomes for this population. This study evaluated young adult performance in internet‐based BWL (IBWL) offering financial incentives for self‐monitoring...
Objective
Identifying novel approaches to combat obesity is important to improve health span. It was hypothesized that methionine restriction (MR) will induce weight loss in obese mice by reducing adipose tissue mass caused by increased energy expenditure and reprogramming of adipose tissue homeostasis. The roles of adiponectin (ADIPOQ) and fibroblast growth factor 21 (FGF21) during weight loss in...
Objective
The obesity epidemic is a public health concern, warranting further research into pharmacological treatments for weight management (WM) as an adjunct to lifestyle interventions. The Semaglutide Treatment Effect in People with obesity (STEP) program aims to investigate the effect of semaglutide versus placebo on weight loss, safety, and tolerability in adults with obesity or overweight....
Objective
The objective of this study was to evaluate the effect of skipping breakfast on body composition and cardiometabolic risk factors.
Methods
This study conducted a systematic review and meta‐analysis of randomized controlled trials (RCTs) evaluating breakfast skipping compared with breakfast consumption. Inclusion criteria included age ≥ 18, intervention duration ≥ 4 weeks, ≥ 7 participants...
Objective
This study aimed to determine the relationship between metabolic flexibility (MetFlex) measured during a euglycemic‐hyperinsulinemic clamp and a prolonged fast. This study also analyzed the association between MetFlex and metabolic health.
Methods
Eighteen healthy men (mean [SD]: 22 [2] years old; BMI: 22 [1] kg/m2) performed two sessions: (1) euglycemic‐hyperinsulinemic clamp (2 mIU/kg...
Objective
People with diabetes show great variability in weight
gain and duration of obesity at the time of diagnosis. BMI trajectories and other cardiometabolic risk factors prior to type 2 diabetes
were investigated.
Methods
A total of 6,223 participants
from the Rotterdam Study cohort were included. BMI patterns before diagnosis of diabetes were identified through latent class
trajectories...
Objective
This study aimed to assess whether metabolically healthy obesity (MHO) increases the risk of diabetes and to explore how the occurrence of metabolic disorders affects the risk of diabetes and which factors determine metabolic health.
Methods
This study examined 49,702 older people without diabetes via the Binhai Health Screening Program in Tianjin.
Results
Compared with individuals...
Objective
The relationship between adipocyte size and ad libitum energy intake has not been previously examined. This study hypothesized an inverse relationship between adipocyte size and daily energy intake (DEI).
Methods
Seventy healthy adults (39 men and 31 women; BMI 30.0 [SD 6.3]) underwent dual‐energy x‐ray absorptiometry and subcutaneous fat biopsies from the abdomen and thigh. Osmium‐fixed...
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